本书从2003年开始在世界范围内（主要是欧美）被用作课程教材，足以证明其影响力。这是第3版，在以前版本的基础上进行了大幅修改。本书的核心理念在于：设计生物过程首先要基于对生物系统的模拟，因此，需要引入生物科学里数学、定量的方法，以期和工程科学完美结合，以指导最佳生物过程的设计，相对于国内大多数生物反应工程教材，本书更注重基础、注重数学方法。这是特别值得借鉴的。
在基础科学部分，本书设计第2、3、4、5章，分别从生物分子、物料守恒、生物反应热力学和生化反应系统四方面介绍生物过程的科学实质、
第6、7、8章，结合前面四章内容，系统总结了酶、细胞、细胞群落三个生物反应过程。侧重于用数学方法描述酶催化、细胞（群落）转化过程，特别重视基础科学和工程科学的结合。
第9、10、11章介绍生物反应中的工程问题，主要包括发酵过程的没计、气液传质以及生物过程放大
本书理念先进，层次清楚，基础和工程结合紧密，特别值得引入国内教育领域。
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《生物反应工程原理(原著第3版)(英文版)》是国外化学经典教材系列(影印版)。
1WhatIsThisBookAbout？
1.1NoteonNomenclature
2ChemicalsfromMetabolicPathways
2.1TheBioreflnery
2.1.1EthanolProduction
2.1.2ProducfionofP1atformChemicalsintheBiorefinery
2.2TheChemistryofMetabolicPathways
2.2.1TheCurrenciesOfGibbsFreeEnergyandofReducing
Power
2.2.2Glycolysis
2.2.3FermentativeMetabolism：OxidationofNADHinAnaerobic
Processes
2.2.4TheTCACycle：ProviderofBuildingBlocksand
NADH／FADH，
2.2.5ProductionofATPbv0xidativePhosphorylation
2.2.6ThePentosePhosphatePathway：AMultipurposeMetabolic
Network
2.2.7SummaryofthePrimaryMetabolismofGlucose
2.3ExamplesofIndustrialProduction0fChemicalsby
Bioprocesses
2.3.1AminoAcids
2.3.2Antibiotics
2.3.3SecretedProteins
2.4DesignofBiotechProcesses：CriteriaforCommercial
Success
2.4.1StrainDesignandSelection
2.4.2CriteriaforDesignandOptimizationofaFermentation
Process
2.4.3StrainImprovement
2.5T11eProspectsoftheBiorefmery
Problems
References
3ElementalandRedoxBalances
3.1TheContinuous.StirredTankReactor
3.1.1MassBalancesforallIdeal.SteadY-StateCorninuousTank
Reactor
3.2YieldCoefncients
3.3BlackBOXStoichiometries
3.4DegreeofReductionBalances
3.4.1ConsistencyTestofExperimentalData
3.4.2RedoxBalancesUsedintheDesignofBioremediation
Processes
3.5SystematicAnalysisofBlackBOXStoichiometries
3.6IdentificationofGrossMeasurementErrors
Problems
References
4ThermodynamicsOfBioreactions
4.1ChemicalEquilibriumandThermodynamicStateFunctions
4.1.1ChangesinFreeEnergyandEnthalpy
4.1.2FreeEnergyChangesinBioreactions
4.1.3Combustion：AChangeinReferenceState
4.2HeatofReaction
4.2.1NonequilibriumThermodynamics
4.2.2FreeEnergyReclaimedbyOxidationintheE1econTransfer
Chajn
4.2.3ProductionofATPMediatedbyF0一F1ATPSynthase
Problems
References
5BiochemicalReactionNetworks
5.1BasicConcepts
5.1.1MetabolicNetworkwithDivergingBranches
5.1.2AFormalMatrix.BasedDescriptionofMetabolic
Networks
5.2GrowthEnergetics
5.2.1ConsumptionofATPforCellularMaintenance
5.2.2EnergeticsofAnaerobicProcesses
5.2.3EnergeticsofAerobicProcesses
……
6EnzymeKineticsandMetabolicControlAnalysis
7GrowthKineticsofCellCultures
8PopulationBalanceEquations
9DesignofFermentationProcesses
10Gas-LiquidMassTransfer
11Scale-UpofBioprocesses
Index
Matrixalgebraisnecessarytounderstand,evenonasuperficiallevel,theconceptsdiscussedinpapersonSystemsBiology,andweintroducematrix-basedMetabolicFluxAnalysisinChap.5.Butthesubjectisintroducedslowlyaftersimplenetworkshavebeenstudiedbymethodsthatrequireverylittlebeyondbasicalgebra.Similarly,attheendofChap.3,methodsthatarenecessarytoevaluatethequalityofexperitnentaldataarediscussed,butonlyaftermanyexampleswhereelementalandredoxbalancesareusedtoanalyzesteady-stateratedataandtoderivethestoichiometryofbioreactions.WheninChap.6reactionscatalyzedbyimmobilizedenzymesaretreated,onemustapplysomebasicconceptsfromtransportphenomena.Diffusionintothepelletsistreatedwiththehelpofdetailedexamples.TheobjectiveistogivethereaderanunderstandingofthetopicwhichisontheparwiththatgiveninstandardtextsonChemicalReactionEngineering.Thebookhasmorethan100examplesandnotes.TheExampleswillhelpthereadertobetterunderstandthetextwhiletopicswhichextendthetext,sometimesbypointingtoapplicationsindifferentareas,aretreatedinNotes.TheteachingoftheexamplesisfurtherextendedintotheProblemsectionsofeachchapter.Someoftheexamplesandproblemsaresimpleillustrationsofthetext,whileothersaredetailedquantitativestudiesrelevantforbuildingupafurtherunderstandingofbio-reactions,bothforuseinscientificstudiesandfordesignofequipment.Thedesignexamplesoftenrefertothecollaborationoftheauthorswithmajorbio-techcompanies-suitablyreformulatedifnecessary.HopefullythesedesignexamplesdemonstratethatBio-reactionEngineering,bycombiningcoresubjectsfromChemicalEngineeringandtheBio-Sciences,contributestosecurebioprocessesaprominentplaceintheprocessindustry.
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